As of the 8:00 update, Tropical Storm Isaac has maximum sustained winds of 60 mph and is moving to the NW at 20 mph. There is already a Hurricane Warning in effect for the Florida Keys and the west coast of Florida from Bonita Beach to Ocean Reef.
The center of Isaac should be near or over the Florida Keys and southern Florida Sunday. The storm is predicted to become a hurricane between Sunday morning and Sunday night. This a very large storm with winds extending out over 200 miles. That means strong winds will extend out farther than in a typical storm. Up to a foot of rain could fall across the southern parts of Florida.
While it seems unlikely that the storm will make a direct impact on the RNC in Tampa, since the storm is so large, there could still be strong winds and heavy rains in the area.
The storm should hit the Gulf Coast in the middle of next week. While it is too early to tell exactly where it will hit, currently the most likely target seems to be the Florida Panhandle or Alabama. From there, it looks like it should move north and could potentially bring rain to the Triad by the end of next week. It will all depend on its interaction with an approaching cold front.
National Hurricane Canter