As the company's home mortgage refinancing business slows down, Wells Fargo will lay off about 150 employees in the Charlotte area.
Nearly 50 workers in Raleigh were also given layoff notices.
Workers were given 60 day notices this week.
A company spokeswoman says most of those being laid off work as mortgage loan processors and adds the bank will try to find other jobs for the employees.
These cuts come after the bank laid off more than 280 workers in Charlotte last month.
WFMY News 2