Cleveland, OH (Sports Network) - Michael Brantley and Casey Kotchman each launched a three-run home run on Wednesday as the Cleveland Indians clobbered the Los Angeles Angels, 12-3, in the finale of a three-game series at Progressive Field.

Asdrubal Cabrera went 2-for-4 with a pair of RBI, while Shin-Soo Choo, Jason Kipnis and Lou Marson all knocked in a run for the Indians, who won for the fifth time in their last seven tries.

Derek Lowe (8-6) allowed three runs on 11 hits and no walks with one strikeout to collect the win. Nick Hagadone, Tony Sipp and Jeremy Accardo closed out the final three innings for the Tribe.

Ervin Santana (4-9) was rocked for eight runs on six hits and three walks in just 1 1/3 innings -- his shortest outing of the season -- to absorb the loss.

Maicer Izturis drove in a pair of runs and Alberto Callaspo added an RBI with a sacrifice fly for the Angels, who have dropped four of their last six games.

The Sports Network